Is it just me or after the last update even the "read only" does not help? The profile settings do not reset after launching the game, but those adjustments don't do anything no more... This is strange.
If you have Aorus\gigabyte motherboard try resetting CMOS. Their motherboards are garbage with unstable glitchy bios which causes poor GPU usage. Also sli does not work in dx12, just use dx11. Good luck.